- beauty pageant: Miss Indiana USA
- edition: 70th
- date: July 26, 2021
- venue: The Paramount Theater, Anderson, Madison County, Indiana, United States
- number of candidates: 24
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CANDIDATES
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TOP 15
- Kennedy Bria Starcevich (Crown Point)
- India Cuttino (Indianapolis)
- Kiki Walls (West Gary)
- Karissa Jaeckel (Roseland)
- Lydia Tremaine (Pride of Indiana)
- Mikayla Eaton (Northwest Indiana)
- Samantha Toney (Greenwood)
- Kelsey Foster (Fort Wayne)
- Grace Bryant (South Bend)
- Lexie Dames (Circle City)
- A’Niyah Birdsong (Anderson)
- Lauren Molella (Marion County)
- Dyna Kristine Martinez (Central)
- Lore’al Avery (Gary)
- Nicole Wallace (Capital City)
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TOP 5
- Lydia Tremaine (Pride of Indiana)
- A’Niyah Birdsong (Anderson)
- Kelsey Foster (Fort Wayne)
- Kiki Walls (West Gary)
- Samantha Toney (Greenwood)
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WINNERS
| PLACEMENT | 2020 | 2021 |
| 4th runner-up | Rose McClimans | Kiki Walls (West Gary) |
| 3rd runner-up | Bailee Zimmerman | Kelsey Foster (Fort Wayne) |
| 2nd runner-up | A’Niyah Birdsong | Lydia Tremaine (Pride of Indiana) |
| 1st runner-up | Samantha Toney | Samantha Toney (Greenwood) |
| MISS INDIANA USA | Alexis Lete (New Albany) | A’Niyah Birdsong (Anderson) |

