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- beauty pageant: Miss Cayman Islands Universe
- edition: 45th
- date: August 6, 2022
- venue: The Westin Grand Cayman Seven Mile Beach Resort and Spa, George Town, Cayman Islands
- hosts: Caitlin Tyson, Mariah Tibbetts
- performers: Rico Rolando, Kendora, Stuart Wilson, Cayman Islands National Dance Company
- candidates: 8
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CANDIDATES
| NAME, AGE, HOMETOWN | SPONSOR |
| Whitney Foster, 28, George Town | Compass Media Cayman |
| Izarah Brown, 20, West Bay | Prestige Motors Cayman |
| Lisa Evans, 27, George Town | One Heart Cayman |
| Carmen Ebanks, 21, George Town | Moxam Time Pieces |
| Hayley Grizzel, 26, George Town | Kirk Freeport |
| Chloe Powery-Doxey, 25, George Town | The Finishing Touch Cayman |
| Tiffany Conolly, 24, West Bay | Island Naturals Cayman |
| Angelina Brown, 20, West Bay | Inspire Cayman Training |
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SPECIAL AWARDS
- Miss Photogenic: Tiffany Conolly (West Bay)
- Miss Personality: Angelina Brown (West Bay)
- People’s Choice: Whitney Foster (George Town)
- Best in Gown: Tiffany Conolly (West Bay)
- Best Smile: Tiffany Conolly (West Bay)
- Best Legs: Chloe Powery-Doxey (George Town)
- Most Improved: Angelina Brown (West Bay)
- Ted Green Ambassador: Chloe Powery-Doxey (George Town)
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WINNERS
| PLACEMENT | 2022 | 2021 |
| 2nd runner-up | Hayley Grizzel George Town | Aliyah Harrison West Bay Ashley Crowe George Town |
| 1st runner-up | Chloe Powery-Doxey George Town | Kimberly Carlos West Bay |
| Miss Cayman Islands Universe | Tiffany Conolly West Bay | Georgina Kerford George Town |
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