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- tournament: United States Open Tennis Championships
- event: women’s singles
- edition: 138th
- venue: USTA Billie Jean King National Tennis Center, New York City, New York, United States
- dates: August 27, 2018-September 9, 2018
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| PLACEMENT | TENNIS PLAYER (COUNTRY) |
| Champion | Naomi Osaka (Japan) |
| Runner-up | Serena Williams (USA) |
| Semifinalists | Anastasija Sevastova (Latvia) Madison Keys (USA) |
| Quarterfinalists | Karolina Pliskova (Czech Republic) Sloane Stephens (USA) Carla Suarez Navarro (Spain) Lesia Tsurenko (Ukraine) |
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