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- tournament: United States Open Tennis Championships
- event: men’s singles
- edition: 141th
- venue: USTA Billie Jean King National Tennis Center, New York City, New York, United States
- dates: August 30, 2021-September 12, 2021
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| PLACEMENT | TENNIS PLAYER (COUNTRY) |
| Champion | Daniil Medvedev (Russia) |
| Runner-up | Novak Djokovic (Serbia) |
| Semifinalists | Félix Auger-Aliassime (Canada) Alexander Zverev (Germany) |
| Quarterfinalists | Matteo Berrettini (Italy) Lloyd Harris (South Africa) Carlos Alcaraz (Spain) Botic van de Zandschulp (Netherlands) |
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