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- tournament: United States Open Tennis Championships
- event: women’s singles
- edition: 141th
- venue: USTA Billie Jean King National Tennis Center, New York City, New York, United States
- dates: August 30, 2021-September 12, 2021
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| PLACEMENT | TENNIS PLAYER (COUNTRY) |
| Champion | Emma Raducanu (England, United Kingdom) |
| Runner-up | Leylah Fernandez (Canada) |
| Semifinalists | Aryna Sabalenka (Belarus) Maria Sakkari (Greece) |
| Quarterfinalists | Karolína Plíšková (Czech Republic) Elina Svitolina (Ukraine) Barbora Krejčíková (Czech Republic) Belinda Bencic (Switzerland) |
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