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- beauty pageant: Señorita Panamá
- edition: 55th
- venue: Hotel Whyndham Convention Center, Panama City, Panama
- date: November 7, 2021
- candidates: 29
- host: Carlos Adyan, Massiel Rodríguez
- performer: Diana Villamonte
- broadcaster: Telemetro
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CANDIDATES
| Top 16 | Valeria Solanilla (Colon) Valentina D’ Alessandro (Costa del Este) Guadalupe Ureña (Isla Barro Colorado) Michelle Cuevas (Isla Coiba) Joselyn Aizprua (Santa Fe) Yolany Canto (Santiago) |
| Top 10 | Karol Suira (Chiriqui) Ariela Combe (Isla del Rey) Amileris Vega (Nata) Julia Marina Leong (Panama Oeste) Ana Sofía Effio (Santa Catalina) |
| Top 5 | Cecilia Medina (Casco Antiguo) Hillary Watson (Isla Colon) Brenda Smith Lezama (Panama Centro) Ivis Nicole Snyder (Pedasi) Katheryn Yejas (Taboga) |
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SPECIAL AWARDS
- Miss Congeniality: Dilliamileth Canales (Isla San Jose)
- Miss Photogenic: Ivis Nicole Snyder (Pedasi)
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WINNERS
| PLACEMENT | 2021 | 2020 |
| 2nd runner-up | Ivis Nicole Snyder Pedasi | N/A |
| 1st runner-up | Hillary Watson Isla Colon | N/A |
| Miss Panama Supranacional Miss Supranational Panama | Cecilia Medina Casco Antiguo | Darelys Yahel Santos Domínguez Panama Norte |
| Miss Panama Grand Miss Grand Panama | Katheryn Yejas Taboga | Angie Keith Bocas del Toro |
| Miss Panama Internacional Miss International Panama | N/A | Valeria Estefanía Franceschi Alvarado Panama Centro |
| Miss Panama Miss Universe Panama | Brenda Smith Lezama Panama Centro | Carmen Isabel Jaramillo Panama Este |
CONAN Daily 